For those interested in numbers, see Kefeng Li (李克峰)’s google scholar citations profile, ORCiD or Scopus.
We try to include links for all of our papers. Some of the links open PDFs, others direct you to a journal’s site where that particular publication is available for download. If you cannot access one of our papers, let us know. The copyright notice for these papers is listed at the bottom of the page.
53. Yuyang Sha, Hongxin Pan, Gang Luo, Caijuan Shi, Wei Chen, Jing Wang, Kefeng Li (2026). MDD-thinker: A reasoning-enhanced large language model for diagnosis of major depressive disorder. Journal of Affective Disorders, 403, 121405. 10.1016/j.jad.2026.121405.
52. J. Ji, Z. Li, A. Xing et al. (2026). Causal relationships between alzheimer’s disease genetics and brain connectivity alterations: a multi-modal mendelian randomization study with transcriptomic validation of 191 rs-fMRI and 635 DTI neuroimaging traits. Brain Imaging and Behavior, 20, 57. 10.1007/s11682-026-01114-0.
51. Zhongwen Feng, Yinglian Wang, Qingliu Lu, Xuefeng Jin, Yunyun Qin, Yixuan Jiang, Xiaoyu Chen, Kefeng Li (2026). Triangulating the link between depression and liver disease: An integrative analysis of genetic, observational, and research trend data. Comprehensive Psychoneuroendocrinology, 26, 100346. 10.1016/j.cpnec.2026.100346.
50. Weiyu Meng, Jiajun Yang, Xi Wang, Xiaobing Zhai, Gang Luo, Yuyang Sha, Hongxin Pan, Wei Xu, Henry HY Tong, Edmundo Patricio Lopes Lao, Ci-Ren Zhong-Ga, Song Cui, Xiantao Song, Kefeng Li (2026). Integrated multi-omics reveals population-specific mechanisms of cardiovascular disease in high-altitude environments. iScience, 29.
49. Junrong Li, Hanyu Cao, Zirun Zhu, Xiaobing Zhai, Abao Xing, Shuowen Zeng, Gang Luo, Yuyang Sha, Peng Li, Kefeng Li (2026). Pipeline-optimized machine learning for chronic fatigue syndrome diagnosis: A lightweight, interpretable model using blood biochemical and metabolomic data. Computational Biology and Chemistry, 123, 108995. 10.1016/j.compbiolchem.2026.108995.
48. J. Wang, G. Luo, P. Lv et al. (2026). Plasma metabolomic signatures in patients with multidrug-resistant bacterial sepsis. Metabolomics, 22, 21. 10.1007/s11306-026-02398-5.
47. T. Chen, C. Xie, W. Zhang et al. (2026). ImageNet pre-training and two-step transfer learning in chromosome image classification. Scientific Reports, 16, 7572. 10.1038/s41598-026-38662-w.
46. Xiuling Ma, Likun Zhao, Hongxin Pan, Zhongwen Feng, Jianlin Lin, Junjun Ji, Junrong Li, Xiaoxia Liu, Jinfeng Wang, Xijun Tang, Kefeng Li (2026). Atlas of human cerebellar aging: nonlinear molecular trajectories reveal multidimensional mechanisms underlying cognitive and motor function regulation. The Journals of Gerontology: Series A, 81(4), glag022. 10.1093/gerona/glag022.
45. Weiyu Meng, Yuyang Sha, Ci-ren Zhong-ga, Hongxin Pan, Xiaobing Zhai, Pu Zhen, Henry H.Y. Tong, Edmundo Patricio Lopes Lao, Hongjia Zhang, Wenzhi Yang, Song Cui, Xiantao Song, Kefeng Li (2026). SMPD1-mediated sphingolipid metabolism dysregulation in predicting and preventing in-stent restenosis of coronary heart disease patients. Journal of Pharmaceutical Analysis, 101553. 10.1016/j.jpha.2026.101553.
44. Xiaoxia Liu, Qiufu Li, Liyuan Zhang, Ying He, Sitao Tan, Xiaoyu Chen, Kefeng Li (2026). Impacts of amino acid supplementation on renal function and nutritional parameters in patients with renal insufficiency: bibliometric analysis and meta-analysis. Frontiers in Nutrition, 12, 1594507.
43. Gang Luo, Wei Xu, Yuyang Sha, Xuechen Zhao, Hongxin Pan, Xiaobing Zhai, Zhifan Li, Weiyu Meng, Junrong Li, Junjun Ji, Li Yu, Kefeng Li (2025). An interpretable machine learning model predicts the interactive and cumulative risks of different environmental chemical exposures on depression. Translational Psychiatry, 10.1038/s41398-025-03651-6.
42. Abao Xing, Tiantian Cai, Haofan Du, Zhifan Li, Hoiman Ng, Junrong Li, Guanmin Jiang, Lijun Chen, Kefeng Li (2025). MRanalysis: A Comprehensive Online Platform for Integrated, Multi-Method Mendelian Randomization and Associated Post-GWAS Analyses. GigaScience, 10.1093/gigascience/giaf131.
41. Baoming Feng, Haofan Du, Henry HY Tong, Xu Wang, Kefeng Li (2025). Enhancing Local Functional Structure Features to Improve Drug–Target Interaction Prediction. International Journal of Molecular Sciences, 10.3390/ijms262010194.
40. Yeqin Liu, Feiyi Xu, Zhongyuan Lv, Kefeng Li, Xiaomin Dong (2025). Causal relationship between PM2. 5 exposure and population-level antidepressant medication use: A Mendelian randomization study using GWAS data from multi-biobank. Environmental Research, 10.1016/j.envres.2025.122192.
39. Yichen Ma, Xiaobing Zhai, Danni Mu, Yumeng Gao, Yuemeng Li, Ling Qiu, Kefeng Li, Xinqi Cheng (2025). Superior prognostic value of estimated small dense LDL cholesterol for cardiovascular risk assessment: evidence from international cohort studies. Lipids in Health and Disease, 10.1186/s12944-025-02717-0.
38. Yuyang Sha, Hongxin Pan, Gang Luo, Caijuan Shi, Jing Wang, Kefeng Li (2025). MDD-Thinker: Towards Large Reasoning Models for Major Depressive Disorder Diagnosis. arXiv preprint arXiv:2509.24217, https://arxiv.org/abs/2509.24217.
37. Yuyang Sha, Hongxin Pan, Weiyu Meng, Kefeng Li (2025). Contrastive knowledge-guided large language models for medical report generation. International Conference on Medical Image Computing and Computer-Assisted Intervention, 10.1007/978-3-032-04978-0_11.
36. Jianlin Lin, Qiletian Wang, Xiaoxia Liu, Miao Zhou, Zhongwen Feng, Xiuling Ma, Junrong Li, Renyou Gan, Xu Wang, Kefeng Li (2025). Causal Inference Framework Reveals Mediterranean Diet Superiority and Inflammatory Mediation Pathways in Mortality Prevention: A Comparative Analysis of Nine Common Dietary Patterns. Foods, 10.3390/foods14173122.
35. Jinping Zheng, Gang Luo, Guowei Wan, Xueyi Chen, Chi Kin Lam, Ziying Wu, Jieying Liu, Junjun Ji, Yuefei Wang, Weiyu Meng, Xiaobing Zhai, Yuyang Sha, Kefeng Li (2025). Urine Exposome–Metabolome Network Analysis Identifies Differential Chemical Connectivity Associated with Mild Cognitive Impairment. Journal of Proteome Research, 10.1021/acs.jproteome.5c00030.
34. Jing Wang, Qixiu Li, Can Xie, Xiaofei Li, Huikao Wang, Wei Xu, Ruyan Lv, Xiaobing Zhai, Ping Xu, Kefeng Li, Xi-Cheng Song (2025). Predicting in-hospital mortality in intensive care unit patients using Causal Survivalnet with serum chloride and other causal factors: cross-country study. Journal of Medical Internet Research, 10.2196/70118.
33. Xiaobing Zhai, Junjun Ji, Jing Wang, Jinji Bai, Xuechen Zhao, Wenjie Zhang, Ruyan Lv, Xuan Deng, Qixiu Li, Weiyu Meng, Qianqian Zhang, Jinyuan Zhao, Jiajing Cui, Li Yu, Chi Kin Lam, Chan Zhang, Henry HY Tong, Yuefei Wang, Xicheng Song, Kaiqiang Wang, Junfeng Li, Kefeng Li (2025). The association between cruciferous vegetable consumption and Perfluorooctanesulfonic acid bioaccumulation: A cross-sectional analysis of the US population and cross-country randomized clinical trial validation. Environmental Chemistry and Ecotoxicology, 10.1016/j.enceco.2025.07.003.
32. Xiaoxia Liu, Qiufu Li, Liyuan Zhang, Ying He, Sitao Tan, Xiaoyu Chen, Kefeng Li (2025). Impacts of amino acid supplementation on renal function and nutritional parameters in patients with renal insufficiency: bibliometric analysis and meta-analysis. Frontiers in Nutrition, 10.3389/fnut.2025.1594507.
31. Qiuhui Yang, Shu Su, Tianyu Zhang, Meng Wang, Weiqiang Dou, Kefeng Li, Ya Ren, Yijia Zheng, Mingwei Wang, Yi Xu, Yue Sun, Zhou Liu, Tao Tan (2025). A deep learning framework for reconstructing Breast Amide Proton Transfer weighted imaging sequences from sparse frequency offsets to dense frequency offsets. Computerized Medical Imaging and Graphics, 10.1016/j.compmedimag.2025.102563.
30. Yuyang Sha, Hongxin Pan, Wei Xu, Weiyu Meng, Gang Luo, Xinyu Du, Xiaobing Zhai, Henry HY Tong, Caijuan Shi, Kefeng Li (2025). MDD-LLM: Towards Accuracy Large Language Models for Major Depressive Disorder Diagnosis.
29. Ying Liu, Kefeng Li, Hoiman Ng, Qianhong Ye, Henry HY Tong (2025). Predicting influenza trends in the context of post-COVID immunity gaps in Macao, China. Journal of Travel Medicine, 10.1093/jtm/taaf035. Full Text
28. Yuyang Sha, Jiasong Xiao, Kefeng Li (2025). Multimodal perception system for real open environment. Sixteenth International Conference on Signal Processing Systems (ICSPS 2024), arxiv.org/pdf/2410.07926. Full Text
27. Wei Xu, Gang Luo, Weiyu Meng, Xiaobing Zhai, Keli Zheng, Ji Wu, Yanrong Li, Abao Xing, Junrong Li, Zhifan Li, Ke Zheng, Kefeng Li (2025). MRAgent: an LLM-based automated agent for causal knowledge discovery in disease via Mendelian randomization. Briefings in Bioinformatics, 10.1093/bib/bbaf140. Full Text
26. Hongxin Pan, Yuyang Sha, Xiaobing Zhai, Gang Luo, Wei Xu, Weiyu Meng, Kefeng Li (2025). Bootstrap inference and machine learning reveal core differential plasma metabolic connectome signatures in major depressive disorder. Journal of Affective Disorders, 10.1016/j.jad.2025.02.109.
25. Wenjie Zhang, Chan Zhang, Jinyuan Zhao, Jiajing Cui, Jinji Bai, Xuan Deng, Junjun Ji, Ting Li, Yu Wang, Kefeng Li, Yunhui Qu, Junfeng Li (2025). Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study. Brain and Behavior, 10.1002/brb3.70416. Full Text
24. Song Cheng, Henry HY Tong, Chaoqing Zhang, Lingyu Jian, Junjun Ji, Ting Li, Yu Wang, Junfeng Li, Kefeng Li (2025). Disorganization of Small‐World Functional Brain Networks in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder. Brain and Behavior, 10.1002/brb3.70323. Full Text
23. Meiting Jiang, Yuyang Sha, Yadan Zou, Xiaoyan Xu, Mengxiang Ding, Xu Lian, Hongda Wang, Qilong Wang, Kefeng Li, De-an Guo, Wenzhi Yang (2025). Integration of deep neural network modeling and LC-MS-based pseudo-targeted metabolomics to discriminate easily confused ginseng species. Journal of Pharmaceutical Analysis, 10.1016/j.jpha.2024.101116. Full Text
22. Yuyang Sha, Qingyue Zhang, Xiaobing Zhai, Menghui Hou, Jingtao Lu, Weiyu Meng, Yuefei Wang, Kefeng Li, Jing Ma (2024). CerviFusionNet: A multi-modal, hybrid CNN-transformer-GRU model for enhanced cervical lesion multi-classification. iScience, 10.1016/j.isci.2024.111313. Full Text
21. Xiaobing Zhai, Henry H. Y. Tong, Chi Kin Lam, Abao Xing, Yuyang Sha, Gang Luo, Weiyu Meng, Junfeng Li, Miao Zhou, Yangxi Huang, Ling Shing Wong, Cuicui Wang, Kefeng Li (2024). Association and causal mediation between marital status and depression in seven countries. Nature Human Behaviour, 10.1016/j.talanta.2024.126750. Full Text
20. Zhifan Li, Yanrong Li, Xinrong Tang, Abao Xing, Jianlin Lin, Junrong Li, Junjun Ji, Tiantian Cai, Ke Zheng, Sai Sachin Lingampelly, Kefeng Li (2024). Causal Metabolomic and Lipidomic Analysis of Circulating Plasma Metabolites in Autism: A Comprehensive Mendelian Randomization Study with Independent Cohort Validation. Metabolites, 10.3390/metabo14100557. Full Text
19. Can Xie, Xiaobing Zhai, Haiyang Chi, Wenxiang Li, Xiaolin Li, Yuyang Sha, Kefeng Li (2024). A Novel Fusion Pruning-Processed Lightweight CNN for Local Object Recognition on Resource-Constrained Devices. IEEE Transactions on Consumer Electronics, 10.1109/TCE.2024.3475517. Full Text
18. Wenjie Zhang, Xiaobing Zhai, Chan Zhang, Song Cheng, Chaoqing Zhang, Jinji Bai, Xuan Deng, Junjun Ji, Ting Li, Yu Wang, Henry HY Tong, Junfeng Li, Kefeng Li (2024). Regional brain structural network topology mediates the associations between white matter damage and disease severity in first-episode, Treatment-naïve pubertal children with major depressive disorder. Psychiatry Research: Neuroimaging, 10.1016/j.pscychresns.2024.111862. Full Text
17. Meiting Jiang, Yuyang Sha, Yadan Zou, Xiaoyan Xu, Mengxiang Ding, Xu Lian, Hongda Wang, Qilong Wang, Kefeng Li, De-an Guo, Wenzhi Yang (2024). Integration of deep neutral network modeling and LC-MS-based pseudo-targeted metabolomics to discriminate easily confused ginseng species. Journal of Pharmaceutical Analysis, 10.1016/j.jpha.2024.101116. Full Text
16. Yuyang Sha, Meiting Jiang, Gang Luo, Weiyu Meng, Xiaobing Zhai, Hongxin Pan, Junrong Li, Yan Yan, Yongkang Qiao, Wenzhi Yang, Kefeng Li (2024). HerbMet: Enhancing metabolomics data analysis for accurate identification of Chinese herbal medicines using deep learning. Phytochemical Analysis, 10.1002/pca.3437. Full Text
15. Siqi Chen, Nan Gao, Chunzhi Li, Fei Zhai, Xiwei Jiang, Peng Zhang, Jibin Guan, Kefeng Li, Rongwu Xiang, Guixia Ling (2024). DrugSK: A Stacked Ensemble Learning Framework for Predicting Drug Combinations of Multiple Diseases. Journal of Chemical Information and Modeling, 10.1021/acs.jcim.4c00296. Full Text
14. Wei Xu, Ruiya Guo, Pengyu Chen, Li Li, Maomao Gu, Hao Sun, Lingyan Hu, Zumin Wang, Kefeng Li (2024). Cherry growth modeling based on Prior Distance Embedding contrastive learning: Pre-training, anomaly detection, semantic segmentation, and temporal modeling. Computers and Electronics in Agriculture, 10.1016/j.compag.2024.108973. Full Text
13. Linlin Bian, Xue Ge, Senwei Feng, Guangxuan Chen, Kefeng Li, Xu Wang (2024). Determination of chloropropanol esters and glycidyl esters in instant noodles based on solid-phase microextraction with chitosan-β-cyclodextrin coated fiber. Food Chemistry, 10.1016/j.foodchem.2024.138419. Full Text
12. Sai Sachin Lingampelly, Jane C Naviaux, Luke S Heuer, Jonathan M Monk, Kefeng Li, Lin Wang, Lori Haapanen, Chelsea A Kelland, Judy Van de Water, Robert K Naviaux (2024). Metabolic network analysis of pre-ASD newborns and 5-year-old children with autism spectrum disorder. Communications Biology, 10.1038/s42003-024-06102-y. Full Text
11. Xue Ge, Senwei Feng, Linlin Bian, Mingjuan Wang, Kefeng Li, Xu Wang (2024). Determination of parabens in breast milk using stir bar sorptive extraction coupled with UHPLC-UV. Talanta, 10.1016/j.talanta.2023.125609. Full Text
10. Kefeng Li, Henry Hoi Yee Tong, Yuwei Chen, Yizhu Sun, Jing Wang (2024). The emerging roles of next-generation metabolomics in critical care nutrition. Critical Reviews in Food Science and Nutrition, 10.1080/10408398.2022.2113761. Full Text
9. Yuyang Sha, Weiyu Meng, Gang Luo, Xiaobing Zhai, Henry HY Tong, Yuefei Wang, Kefeng Li (2024). MetDIT: Transforming and Analyzing Clinical Metabolomics Data with Convolutional Neural Networks. Analytical Chemistry, 10.1021/acs.analchem.3c04607. Full Text
8. Jing Wu, Huijie Feng, Yaxiong Zhao, Junfeng Li, Ting Li, Kefeng Li (2024). Neuroimaging features in a patient with non-ketotic hyperglycaemic seizures: A case report. World Journal of Clinical Cases, 10.12998/wjcc.v12.i5.1004. Full Text
7. Weiyu Meng, Hongxin Pan, Yuyang Sha, Xiaobing Zhai, Abao Xing, Sai Sachin Lingampelly, Srinivasa R Sripathi, Yuefei Wang, Kefeng Li (2024). Metabolic Connectome and Its Role in the Prediction, Diagnosis, and Treatment of Complex Diseases. Metabolites, 10.3390/microorganisms12010148. Full Text
6. Abao Xing, Hoi Man Ng, Huining Jiao, Kefeng Li, Qianhong Ye (2024). The Prevalence, Epidemiological, and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus (MRSA) in Macau (2017–2022). Microorganisms, 10.3390/microorganisms12010148. Full Text
5. Junrong Li, Xiaobing Zhai, Jixing Liu, Chi Kin Lam, Weiyu Meng, Yuefei Wang, Shu Li, Yapeng Wang, Kefeng Li (2024). Integrated Causal Inference Modeling Uncovers Novel Causal Factors and Potential Therapeutic Targets of Qingjin Yiqi Granules for Chronic Fatigue Syndrome. Acupuncture and Herbal Medicine, 10.1097/HM9.0000000000000098. Full Text
4. Lisa A Pan, Jane C Naviaux, Lin Wang, Kefeng Li, Jonathan M Monk, Sai Sachin Lingampelly, Anna Maria Segreti, Kaitlyn Bloom, Jerry Vockley, Mark A Tarnopolsky, David N Finegold, David G Peters, Robert K Naviaux (2023). Metabolic features of treatment-refractory major depressive disorder with suicidal ideation. Translational psychiatry, 10.1038/s41398-023-02696-9. Full Text
3. Yuyang Sha, Weiyu Meng, Xiaobing Zhai, Can Xie, Kefeng Li (2023). Accurate Facial Landmark Detector via Multi-scale Transformer. Pattern Recognition and Computer Vision, 10.1007/978-981-99-8469-5_22. Full Text
2. Abao Xing, Henry H Y Tong, Songyan Liu, Xiaobing Zhai, Li Yu, Kefeng Li (2023). The causal association between obesity and gastric cancer and shared molecular signatures: a large-scale Mendelian randomization and multi-omics analysis. Frontiers in Oncology, 26;13:1091958. doi:10.3389/fonc.2023.1091958. Full Text
1. Yuyang Sha, Xiaobing Zhai, Junrong Li, Weiyu Meng, Henry H.Y. Tong, Kefeng Li (2023). A novel lightweight deep learning fall detection system based on global-local attention and channel feature augmentation. Interdisciplinary Nursing Research, 2(2), 68-75. doi:10.1097/NR9.0000000000000026. Full Text
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